ML 210 - CID 49766530

Name	ML-210
Synonyms	ML 210 ML-210 CID 49766530 ML 210 - CID 49766530 (4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)- [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
CAS	1360705-96-9

Molecular Formula	C22H20Cl2N4O4
Molar Mass	475.32
Density	1.415±0.06 g/cm3(Predicted)
Boling Point	644.7±55.0 °C(Predicted)
Solubility	2.5mg/mL in DMSO,10mg/mL in DMF, slightly soluble in ethanol
Appearance	powder
Color	white to beige
pKa	4.69±0.10(Predicted)
Storage Condition	2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Use	ML-210 is a selective, covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds GPX4 selenocysteine residues. ML210 has anticancer activity.
In vitro study	ML-210 exhibits cell-killing activity across a panel of 821 cancer cell lines (WM88, LOX-IMVI, CJM, U257, CAKI2, A498, HT1080, MC38, PANC02). ML-210 is a prodrug that requires cellular activation to bind GPX4. ML-210 has IC 50 s of 71 nM, 272 nM and 107nM for BJeLR (HRAS V12 ), BJeH-LT (without HRAS V12 ) and DRD cell lines, respectively.

WGK Germany

Last Update：2024-01-02 23:10:35

biological activity	ML-210 (CID 49766530) is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4), its EC50 value is 0.04 μm, which can induce Iron death. ML-210 can selectively kill cells that induce the expression of mutant RAS, and has anti-cancer activity.
Target	Value
RAS ()
GPX4 (Cell-free assay)	0.04 μM(EC50)

Last Update：2024-04-09 21:04:16

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Product Name: ML-210 Visit Supplier Webpage Request for quotation
CAS: 1360705-96-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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ML 210 - CID 49766530

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